Trong-Kha Truong, Ph.D.[Edit Page]

Associate Professor

Department of Radiology

Medical Physics Graduate Program

Research Interests and Representative Publications

My research involves the development of innovative magnetic resonance imaging (MRI) coil technologies, image acquisition and reconstruction methods, artifact correction methods, and contrast mechanisms for various MRI applications in the human brain and body, such as diffusion-weighted imaging (DWI), diffusion tensor imaging (DTI), and functional MRI (fMRI).

 

1. Novel coil technologies for MRI with localized B0 shimming and wireless communication

 

Magnetic susceptibility differences at air/tissue interfaces induce localized inhomogeneities in the static magnetic field (B0), resulting in image artifacts such as distortions and signal loss, which hamper many MRI applications. My research involves the development of novel integrated parallel reception, excitation, and shimming (iPRES) coil designs and integrated radio-frequency/wireless coil designs, which enable image acquisition, localized B0 shimming, and/or wireless communication with a single coil array, as well as their application in brain, abdominal, breast, and spinal cord imaging.
Darnell D, Cuthbertson J, Robb F, Song AW, Truong TK* (2019). Integrated radio-frequency/wireless coil design for simultaneous MR image acquisition and wireless communication. Magn Reson Med 81(3): 2176-2183. [PubMed] [full text]
Darnell D, Ma Y, Wang H, Robb F, Song AW, Truong TK* (2018). Adaptive integrated parallel reception, excitation, and shimming (iPRES-A) with microelectromechanical systems switches. Magn Reson Med 80(1): 371-379. [PubMed] [full text]
Darnell D, Truong TK*, Song AW (2017). Integrated parallel reception, excitation, and shimming (iPRES) with multiple shim loops per radio-frequency coil element for improved B0 shimming. Magn Reson Med 77(5): 2077-2086. [PubMed] [full text]
Truong TK*, Darnell D, Song AW (2014). Integrated RF/shim coil array for parallel reception and localized B0 shimming in the human brain. NeuroImage 103: 235-240. [PubMed] [full text]
Han H, Song AW, Truong TK* (2013). Integrated parallel reception, excitation, and shimming (iPRES). Magn Reson Med 70(1): 241-247. [PubMed] [full text]

 

2. Novel acquisition/reconstruction methods for DTI

 

DTI is widely used to investigate the structural connectivity of the human brain, but is limited by a low spatial resolution and a high vulnerability to image artifacts caused by susceptibility effects, eddy currents, and subject motion. My research involves the development of novel acquisition and reconstruction methods that can provide high-resolution high-quality DTI data, enabling new applications such as the investigation of the diffusion anisotropy in the human cortical gray matter in vivo, which will be valuable to assess the cortical microstructure noninvasively and to detect cortical abnormalities in neurological disorders.
Truong TK, Song AW, Chen NK (2015). Correction for eddy current-induced echo-shifting effect in partial-Fourier diffusion tensor imaging. Biomed Res Int 2015: 185026. [PubMed] [full text]
Truong TK*, Guidon A, Song AW (2014). Cortical depth dependence of the diffusion anisotropy in the human cortical gray matter in vivo. PLOS ONE 9(3): e91424. [PubMed] [full text]
Truong TK*, Guidon A (2014). High-resolution multishot spiral diffusion tensor imaging with inherent correction of motion-induced phase errors. Magn Reson Med 71(2): 790-796. [PubMed] [full text]
Truong TK*, Chen NK, Song AW (2012). Inherent correction of motion-induced phase errors in multishot spiral diffusion-weighted imaging. Magn Reson Med 68(4): 1255-1261. [PubMed] [full text]
Truong TK*, Chen NK, Song AW (2011). Dynamic correction of artifacts due to susceptibility effects and time-varying eddy currents in diffusion tensor imaging. NeuroImage 57(4): 1343-1347. [PubMed] [full text]
Truong TK*, Chen B, Song AW (2008). Integrated SENSE DTI with correction of susceptibility- and eddy current-induced geometric distortions. NeuroImage 40(1): 53-58. [PubMed] [full text]

 

3. Novel acquisition/reconstruction methods and contrast mechanisms for fMRI

 

Blood oxygenation level-dependent (BOLD) fMRI is widely used to investigate the function of the human brain, but is an indirect measure of neuronal activity with a low temporal resolution. My research involves the development of novel acquisition and reconstruction methods to improve the sensitivity and specificity of fMRI as well as novel contrast mechanisms that can noninvasively and directly image neuroelectric activity, with a combination of spatial and temporal specificity that is beyond what can be achieved with existing neuroimaging techniques.
Truong TK*, Roberts KC, Woldorff MG, Song AW (2019). Toward direct MRI of neuro-electro-magnetic oscillations in the human brain. Magn Reson Med 81(6): 3462-3475. [PubMed] [full text]
Truong TK*, Chen NK, Song AW (2010). Application of k-space energy spectrum analysis for inherent and dynamic B0 mapping and deblurring in spiral imaging. Magn Reson Med 64(4): 1121-1127. [PubMed] [full text]
Truong TK*, Song AW (2009). Cortical depth dependence and implications on the neuronal specificity of the functional apparent diffusion coefficient contrast. NeuroImage 47(1): 65-68. [PubMed] [full text]
Truong TK*, Song AW (2008). Single-shot dual-z-shimmed sensitivity-encoded spiral-in/out imaging for functional MRI with reduced susceptibility artifacts. Magn Reson Med 59(1): 221-227. [PubMed] [full text]
Truong TK*, Avram A, Song AW (2008). Lorentz effect imaging of ionic currents in solution. J Magn Reson 191(1): 93-99. [PubMed] [full text]
Truong TK, Song AW (2006). Finding neuroelectric activity under magnetic-field oscillations (NAMO) with magnetic resonance imaging in vivo. Proc Natl Acad Sci USA 103(33): 12598-12601. [PubMed] [full text]
Truong TK*, Wilbur JL, Song AW (2006). Synchronized detection of minute electrical currents with MRI using Lorentz effect imaging. J Magn Reson 179(1): 85-91. [PubMed] [full text]