Trong-Kha Truong, Ph.D.[Edit Page]

Assistant Professor

Department of Radiology

Medical Physics Graduate Program

M.S., 2000, Swiss Federal Institute of Technology Lausanne (Physics)

Ph.D., 2004, The Ohio State University (Biomedical Engineering)

Research Interests and Representative Publications

My research interests include the development of novel MRI hardware, contrast mechanisms, pulse sequences, image reconstruction methods, and artifact correction methods to improve the sensitivity and specificity of neuroimaging techniques such as functional MRI (fMRI) and diffusion tensor imaging (DTI).

 

1. Integrated Parallel Reception, Excitation, and Shimming (iPRES)

 

Magnetic susceptibility differences at air/tissue interfaces induce static magnetic field (B0) inhomogeneities, resulting in image artifacts, which hamper many MRI applications. Whole-body spherical harmonic shim coils cannot shim these localized B0 inhomogeneities, whereas multi-coil shimming requires an additional array of localized shim coils near the radiofrequency (RF) coil, resulting in a reduced signal-to-noise ratio (SNR) or shimming performance. To address these limitations, my research involves the development of novel iPRES head and body coil arrays, in which RF currents and direct currents (DC) can flow in the same coil elements, thereby enabling RF excitation/reception and localized B0 shimming with a single coil array, without compromising the SNR or shimming performance.
Darnell D, Truong TK*, Song AW (2016). Integrated parallel reception, excitation, and shimming (iPRES) with multiple shim loops per radio-frequency coil element for improved B0 shimming. Magn Reson Med. [PubMed] [full text]
Truong TK*, Darnell D, Song AW (2014). Integrated RF/shim coil array for parallel reception and localized B0 shimming in the human brain. NeuroImage 103: 235-240. [PubMed] [full text]
Han H, Song AW, Truong TK* (2013). Integrated parallel reception, excitation, and shimming (iPRES). Magn Reson Med 70(1): 241-247. [PubMed] [full text]

 

2. Direct MRI of neuroelectric activity

 

Neuroimaging techniques are widely used to investigate the function of the human brain, but none are currently able to accurately localize neuronal activity with both a high spatial and temporal resolution. Functional MRI (fMRI) based on the blood oxygenation level-dependent (BOLD) contrast is an indirect measure of neuronal activity and is limited by a very low temporal resolution, whereas scalp-recorded electroencephalography (EEG) and magnetoencephalography (MEG) are limited by a poor spatial resolution. To address these limitations, my research involves the development of novel MRI contrast mechanisms that can noninvasively and directly image neuroelectric activity with a much higher spatial and temporal specificity than what can be achieved with any existing neuroimaging techniques.
Pourtaheri N, Truong TK*, Henriquez CS (2013). Electromagnetohydrodynamic modeling of Lorentz Effect Imaging. J Magn Reson 236: 57-65. [PubMed] [full text]
Song AW, Truong TK, Woldorff M (2009). Dynamic MRI of small electrical activity. In: Hyder F, ed. Dynamic brain imaging: multi-modal methods and in vivo applications. New York, NY: Humana Press. pp. 297-315. [PubMed] [full text]
Truong TK*, Avram A, Song AW (2008). Lorentz effect imaging of ionic currents in solution. J Magn Reson 191(1): 93-99. [PubMed] [full text]
Truong TK, Song AW (2006). Finding neuroelectric activity under magnetic-field oscillations (NAMO) with magnetic resonance imaging in vivo. Proc Natl Acad Sci USA 103(33): 12598-12601. [PubMed] [full text]
Truong TK*, Wilbur JL, Song AW (2006). Synchronized detection of minute electrical currents with MRI using Lorentz effect imaging. J Magn Reson 179(1): 85-91. [PubMed] [full text]

 

3. High-resolution and high-fidelity diffusion tensor imaging (DTI)

 

DTI is widely used to investigate the structural connectivity of the human brain, but is currently limited by a low spatial resolution and by a high vulnerability to image artifacts caused by susceptibility effects, eddy currents, and subject motion. My research involves the development of novel acquisition and reconstruction methods to address these issues and to obtain high-quality, high-resolution DTI data, thus enabling new applications such as the investigation of the cortical depth dependence of the diffusion anisotropy in the human cortical gray matter in vivo.
Hu Z, Ma X, Truong TK, Song AW, Guo H (2016). Phase-updated regularized SENSE for navigator-free multi-shot diffusion imaging. Magn Reson Med. [PubMed] [full text]
Chu ML, Chang HC, Chung HW, Truong TK, Bashir MR, Chen NK (2015). POCS-based reconstruction of multiplexed sensitivity encoded MRI (POCSMUSE): a general algorithm for reducing motion-related artifacts. Magn Reson Med 74(5): 1336-1348. [PubMed] [full text]
Truong TK, Song AW, Chen NK (2015). Correction for eddy current-induced echo-shifting effect in partial-Fourier diffusion tensor imaging. Biomed Res Int 2015: 185026. [PubMed] [full text]
Truong TK*, Guidon A, Song AW (2014). Cortical depth dependence of the diffusion anisotropy in the human cortical gray matter in vivo. PLOS ONE 9(3): e91424. [PubMed] [full text]
Avram AV, Guidon A, Truong TK, Liu C, Song AW (2014). Dynamic and inherent B0 correction for DTI using stimulated echo spiral imaging. Magn Reson Med 71(3): 1044-1053. [PubMed] [full text]
Truong TK*, Guidon A (2014). High-resolution multishot spiral diffusion tensor imaging with inherent correction of motion-induced phase errors. Magn Reson Med 71(2): 790-796. [PubMed] [full text]
Truong TK*, Chen NK, Song AW (2012). Inherent correction of motion-induced phase errors in multishot spiral diffusion-weighted imaging. Magn Reson Med 68(4): 1255-1261. [PubMed] [full text]
Truong TK*, Chen NK, Song AW (2011). Dynamic correction of artifacts due to susceptibility effects and time-varying eddy currents in diffusion tensor imaging. NeuroImage 57(4): 1343-1347. [PubMed] [full text]
Truong TK*, Chen B, Song AW (2008). Integrated SENSE DTI with correction of susceptibility- and eddy current-induced geometric distortions. NeuroImage 40(1): 53-58. [PubMed] [full text]

 

4. High-fidelity functional MRI

 

My research also involves the development of novel acquisition and reconstruction methods and contrast mechanisms to improve the sensitivity and specificity of fMRI, as well as their applications in neuroscience.
Hayes SM, Baena E, Truong TK, Cabeza R (2010). Neural mechanisms of context effects on face recognition: automatic binding and context shift decrements. J Cog Neurosci 22(11): 2541-2554. [PubMed]
Truong TK*, Chen NK, Song AW (2010). Application of k-space energy spectrum analysis for inherent and dynamic B0 mapping and deblurring in spiral imaging. Magn Reson Med 64(4): 1121-1127. [PubMed] [full text]
Song AW, Truong TK (2010). Apparent diffusion coefficient dependent fMRI: spatiotemporal characteristics and implications on calibrated fMRI. Int J Imag Sys Tech 20(1): 42-50. [full text]
Smith DV, Hayden BY, Truong TK, Song AW, Platt ML, Huettel SA (2010). Distinct value signals in anterior and posterior ventromedial prefrontal cortex. J Neurosci 30(7): 2490-2495. [PubMed] [full text]
Truong TK*, Song AW (2009). Cortical depth dependence and implications on the neuronal specificity of the functional apparent diffusion coefficient contrast. NeuroImage 47(1): 65-68. [PubMed] [full text]
Truong TK*, Song AW (2008). Single-shot dual-z-shimmed sensitivity-encoded spiral-in/out imaging for functional MRI with reduced susceptibility artifacts. Magn Reson Med 59(1): 221-227. [PubMed] [full text]
Song AW, Guo H, Truong TK (2007). Single-shot ADC imaging for fMRI. Magn Reson Med 57(2): 417-422. [PubMed] [full text]