Jim Voyvodic, Ph.D.[Edit Page]

Associate Professor, Radiology

BS, 1976, Yale University (Physics)

PhD, 1988, Washington University, St. Louis (Neural Science)

Research Interests

Functional organization of visual cortex, diagnostic clinical fMRI, quantitative fMRI, real-time image processing and 3D graphics.

Research Statement

My lab is involved in the development and application of functional MRI in two major areas of research. My neurobiology focus is in using fMRI to study information processing mechanisms in the nervous system. I am particularly interested in how the visual system represents 3-dimensional depth in processing visual scenes. We address this issue with a combination of visual perception tasks and functional MRI using novel analysis tools for high resolution mapping of visual activity. The results indicate that 3-D scene segmentation is central to visual information processing in primary and extra-striate regions of visual cortex.

My second major research focus is in applying functional MRI as a clinical tool to aid in the treatment of brain tumors and epilepsy. Although fMRI is now used clinically to map eloquent cortex in patients, it is not yet reliable enough to be used as a routine procedure. My lab is therefore actively involved in transforming fMRI into a reliable quantitative imaging method. This work has focused on two related questions: How to improve fMRI reproducibility? and How sensitive is fMRI to quantitative changes in brain function? Using novel image processing algorithms we have shown greatly increased reproducibility for fMRI mapping of both motor and language function. Current efforts focus on extending this to improve quantitative sensitivity to changes in brain activity levels.

Recent Representative Publications


Voyvodic JT, Petrella JR & Firedman AH (2009). fMRI activation mapping as a percentage of local excitation: Consistent presurgical motor maps without threshold adjustment. Journal of Magnetic Resonance Imaging. 4: 751-9.


Petrella JP, Shah LM, Harris KT, Friedman AH, George TM, Sampson JH, Pekala JS & Voyvodic JT (2006). Preoperative functional MR imaging localization of language and motor areas: effect on therapeutic decision making in patients with potentially resectable brain tumors. Radiology. 240(3): 793-802.


Voyvodic JT (2006). Activation mapping as a percentage of local excitation: fMRI stability within scans, between scans and across field strengths. Magnetic Resonance Imaging. 24(9): 1949-61.


LaBar KS, Crupain MJ, Voyvodic JT & McCarthy G (2003). Dynamic perception of facial affect and identity in the human brain. Cerebral Cortex. 13(10): 1023-33.


Voyvodic JT (1999). Real-time fMRI paradigm control, physiology, and behavior combined with near real-time statistical analysis. NeuroImage. 10(2): 91-106.


Thulborn KR, Chang SY, Shen GX & Voyvodic JT (1997). High-resolution echo-planar fMRI of human visual cortex at 3.0 Tesla. Harvard Review of Psychiatry. 10(4-5): 183-190.


Voyvodic JT (1996). Cell death in cortical development: How much? Why? So what?. Neuron. 16(4): 693-696.


Voyvodic JT, Burne JT & Raff MC (1995). Quantification of normal cell death in the rat retina: Implications for clone composition in cell lineage analysis. European Journal of Neuroscience. 7(12): 2469-2478.


Voyvodic JT (1989). Target size regulates calibre and myelination of sympathetic axons. Nature. 342(6248): 430-433.

Duke University Academic Affiliations

Department of Radiology (primary)
Department of Neurobiology (secondary)